Hearts & worms
About this resource
- Appropriate grades
- 6–8
- Subjects
- science (general, biology and life science, technology and innovation), thinking skills (information literacy)
- Provider
- American Association for the Advancement of Science
Legal
This catalog record is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 2.5 License. This license applies to the content of this page only and does not apply to the referenced website.
In this Science Update, students explore how a simple worm provides a model for testing drug effects on the human heart. The roundworm known as the C. elegans has a pharynx, or feeding tube that beats rhythmically, has similar electrical properties and genes to the human heart. Christina Petersen, an anesthesiology professor at Vanderbilt University, and her team examine why drugs that block a potassium channel called HERG sometimes trigger fatal heart arrhythmias. Simple worms give them insight as to how human proteins react to the drug. Science NetLinks provides a link to the audio file, a written transcript, helpful definitions for technical terms, and questions to engage students in discussion about whether or not the worm is a good model for the human heart and other possible examples of models that mimic human systems. This lesson also contains links to the University of Wooster’s introduction to C. elegans and another site that provides research and information about this type of worm.
North Carolina Curriculum Alignment
Science (2005)
Grade 6
- Goal 1: The learner will design and conduct investigations to demonstrate an understanding of scientific inquiry.
- Objective 1.01: Identify and create questions and hypotheses that can be answered through scientific investigations.
- Objective 1.05: Analyze evidence to:
- Explain observations.
- Make inferences and predictions.
- Develop the relationship between evidence and explanation.
- Objective 1.08: Use oral and written language to:
- Communicate findings.
- Defend conclusions of scientific investigations.
- Objective 1.09: Use technologies and information systems to:
- Research.
- Gather and analyze data
- Visualize data.
- Disseminate findings to others.
- Objective 1.10: Analyze and evaluate information from a scientifically literate viewpoint by reading, hearing, and/or viewing:
- Scientific text.
- Articles.
- Events in the popular press.
- Goal 2: The learner will demonstrate an understanding of technological design.
- Objective 2.02: Use information systems to:
- Identify scientific needs, human needs, or problems that are subject to technological solution.
- Locate resources to obtain and test ideas.
- Objective 2.03: Evaluate technological designs for:
- Application of scientific principles.
- Risks and benefits.
- Constraints of design.
- Consistent testing protocols.
- Objective 2.02: Use information systems to:
Grade 7
- Goal 1: The learner will design and conduct investigations to demonstrate an understanding of scientific inquiry.
- Objective 1.01: Identify and create questions and hypotheses that can be answered through scientific investigations.
- Objective 1.05: Analyze evidence to:
- Explain observations.
- Make inferences and predictions.
- Develop the relationship between evidence and explanation.
- Objective 1.08: Use oral and written language to:
- Communicate findings.
- Defend conclusions of scientific investigations.
- Objective 1.09: Use technologies and information systems to:
- Research.
- Gather and analyze data.
- Visualize data.
- Disseminate findings to others.
- Objective 1.10: Analyze and evaluate information from a scientifically literate viewpoint by reading, hearing, and/or viewing:
- Scientific text.
- Articles.
- Events in the popular press.
- Goal 2: The learner will demonstrate an understanding of technological design.
- Objective 2.02: Use information systems to:
- Identify scientific needs, human needs, or problems that are subject to technological solution.
- Locate resources to obtain and test ideas.
- Objective 2.03: Evaluate technological designs for:
- Application of scientific principles.
- Risks and benefits.
- Constraints of design.
- Consistent testing protocols.
- Objective 2.02: Use information systems to:
Grade 8
- Goal 1: The learner will design and conduct investigations to demonstrate an understanding of scientific inquiry.
- Objective 1.01: Identify and create questions and hypotheses that can be answered through scientific investigations.
- Objective 1.05: Analyze evidence to:
- explain observations.
- make inferences and predictions.
- develop the relationship between evidence and explanation.
- Objective 1.08: Use oral and written language to:
- Communicate findings.
- Defend conclusions of scientific investigations.
- Describe strengths and weaknesses of claims, arguments, and/or data.
- Objective 1.09: Use technologies and information systems to:
- Research.
- Gather and analyze data.
- Visualize data.
- Disseminate findings to others.
- Objective 1.10: Analyze and evaluate information from a scientifically literate viewpoint by reading, hearing, and/or viewing:
- Scientific text.
- Articles.
- Events in the popular press.
- Goal 2: The learner will demonstrate an understanding of technological design.
- Objective 2.02: Use information systems to:
- Identify scientific needs, human needs, or problems that are subject to technological solution.
- Locate resources to obtain and test ideas.
- Objective 2.03: Evaluate technological designs for:
- Application of scientific principles.
- Risks and benefits.
- Constraints of design.
- Consistent testing protocols.
- Objective 2.02: Use information systems to:
