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- The Columbian Exchange
- In Prehistory, contact, and the Lost Colony, page 5.1
- When Christopher Columbus and his crew arrived in the New World, two biologically distinct worlds were brought into contact. The animal, plant, and bacterial life of these two worlds began to mix in a process called the Columbian Exchange. The results of this exchange recast the biology of both regions and altered the history of the world.
- Format: article
- By J.R. McNeill.
- The Columbian Exchange at a glance
- In Prehistory, contact, and the Lost Colony, page 5.2
- Countless animals, plants, and microorganisms crossed the Atlantic Ocean with European explorers and colonists in the sixteenth, seventeenth, and eighteenth centuries. This chart lists some of the organisms that had the greatest impact on human society worldwide.
- Format: article
- Disease and catastrophe
- In Prehistory, contact, and the Lost Colony, page 5.3
- Of all the kinds of life exchanged when the Old and New Worlds met, lowly germs had the greatest impact. Europeans and later Africans brought smallpox and a host of other diseases with them to America, where those diseases killed as much as 90 percent of the native population of two continents. Europeans came away lucky -- with only a few tropical diseases from Africa and, probably, syphilis from the New World. In America, disease destoyed civilizations.
- Format: article
- By David Walbert.
- Diseases: A brief guide to causes, symptoms, history, and treatment
- Since the beginning of human existence on the planet, diseases have played a significant role in the events of every era. This brief listing of some of the most notorious diseases explains their causes, symptoms, history, prevention, and treatment, and provides links to further information.
- Format: article
- By Emily Jack.
- The fate of North Carolina's native peoples
- In Colonial North Carolina, page 3.8
- After the Tuscarora War (1711–1713) and Yamasee War (1715–1716), only the Cherokee among North Carolina's native peoples remained intact. The Coastal Plain and Piedmont were effectively cleared for European settlement.
- Format: article
- By David Walbert.
- The founding of Virginia
- In Colonial North Carolina, page 1.1
- England planted its first successful North American colony at Jamestown in 1607, but settlers fought Indians and disease, and the colony grew slowly. By the end of the seventeenth century, Virginia had established tobacco as its main crop, a representative government, and slavery as a dominant system of labor.
- Format: article
- By L. Maren Wood.
- Smallpox
- In Prehistory, contact, and the Lost Colony, page 5.4
- Smallpox is a serious, contagious, and sometimes fatal infectious disease caused by the variola virus. Historically, smallpox had a mortality rate of as much as 30 percent. In the Americas, it killed as much as 90 percent of the indigenous population after contact with Europeans introduced the disease. Smallpox is now eradicated after a successful worldwide vaccination program.
- Format: article
- Smallpox victim

- This photograph of a smallpox victim appeared in the Baltimore Health News in 1939.
- Format: image/photograph
- Spain and America: From Reconquest to Conquest
- In Prehistory, contact, and the Lost Colony, page 3.1
- In 1491, no European knew that North and South America existed. By 1550, Spain -- a small kingdom that had not even existed a century earlier -- controlled the better part of two continents and had become the most powerful nation in Europe. In half a century of brave exploration and brutal conquest, both Europe and America were changed forever.
- Format: article
- By David Walbert.
- Summary of a report sent to Bethlehem
- In Diary of a journey of Moravians, page 16
- In Colonial North Carolina, page 5.4
- In 1733, a group of Moravians -- a Protestant Christian denomination originating in fourteenth-century Bohemia -- moved from Europe to North America seeking freedom from religious persecution. In 1753, a group of twelve single brothers left Bethlehem, Pennsylvania, for a new settlement in North Carolina. Their report back to Bethlehem describes what they found in their new home. Includes historical commentary.
- Format: report
- Understanding the Columbian Exchange
- In Two worlds: Educator's guide, page 5.1
- This lesson will help students think about the effects of the Columbian Exchange, particularly the exchange of disease as it affected the psychology of the Europeans and Native populations in the early settlement of the Americas.
- Format: lesson plan (grade 8 Social Studies)
- By Pauline S. Johnson.
- The way Germans did it / The way North Carolinians do it

- A pair of cartoons from the State Health Bulletin in October 1919 warns North Carolinians of how influenza is spread. The first, showing a man gunning down a soldier with a machine gun, is captioned "The way the Germans did it at Chateau-Thierry: During the...
- Format: image/cartoon
- Yaws

- Format: image/photograph